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          廣東威爾醫院,wellclinic,威爾醫院骨科
          醫院公益
          特邀專家

          門診時間(無假日醫院)
          早上8:00 - 晚上21:00

          緊急聯系電話:020-38063333

          王國慧  M.D., 博士 
           
          休斯頓麥迪康醫學咨詢公司 創始人,CEO

          聯合醫生集團顧問醫生

          學習經歷
          2013. 4-2015. 8         Baylor College of Medcicine 博士后
          2004.9-2007.6          中山大學腫瘤學博士
          1998.9-2001.7          中山醫科大學研究生核醫學專業
          1991.9-1996.7          河南醫科大學臨床醫學系

          工作情況
          2013-5-至今               河南省腫瘤醫院兼職副主任醫師
          2013. 4-2015. 8         Baylor College of Medcicine 博士后
          2013. 4-2015. 8         Houston Methodist 研究所博士后
          2011.1-2013.5           中山大學腫瘤防治中心影像與介入中心醫師
          2008.8-2011.1           美國韋恩州立大學醫學院博士后
          2008.3-2008.7           中山大學腫瘤防治中心影像與介入中心主治醫師
          2005.7-2006.7           澳大利亞墨爾本Peter MacCallum Cancer Centre ,PET/CT中心進修學習PET/CT技術及分子影像學
          2001.7-2005.7           中山大學腫瘤防治中心核醫學科主治醫師

          承擔科研課題
          1. 腫瘤防治中心單病種課題:PET/CT在鼻咽癌中的應用研究
          2. 2004年國家自然基金:TK自殺基因用于鼻咽癌靶向治療與基因顯像的實驗研究
          3. 2011年 腫瘤醫院回國資助:ERLIN2一個新的乳腺癌癌基因功能研究及靶向治療的實驗研究
          4.  2013年國家自然基金: ERLIN2 促進乳腺癌細胞生長及調控Herceptin 耐藥性的分子機制研究, 70萬
           
          雜志審稿人:  
          1.  Oral Oncology
          2.  Journal of Medical Imaging and Radiation Oncology
          3.  Journal of Analytical Oncology
          4.  The Hellenic Journal of Nuclear Medicine
          5.  Acta Pharmacologica Sinica
          6.  實用腫瘤學雜志
          7.  The Chinese-German Journal of Clinical Oncology
          8.  Plos one
           
          發表文章
          1.Ze Zheng, Guohui Wang, Li Li, Jeffery Tseng, Fei Sun, Xuequn Chen, Lin Chang, Henry Heng, Kezhong Zhang. Transcriptional signatures of unfolded protein response implicate the limitation of animal models in pathophysiological studies.  Enviromental disease. 2016, 1 (1): 24-30
          2.Xiaoli Cheng, Wenli Shi, Canguo Zhao,Dan Zhang,Piao Liang,Guohui Wang(co-corresponding author) ,Li Lu. Triptolide sensitizes human breast cancer cells to tumor necrosis factor‑α‑induced apoptosis by inhibiting activation of the nuclear factor‑κB pathway. Mol Med Rep. 2016 Feb 23. doi: 10.3892/mmr.2016.4931. [Epub ahead of print]

              Dong Xu, Renduo Song, Guohui Wang, Prince V.S. Jeyabal, Amanda M. Weiskoff, Kefeng Ding, Zheng-Zheng Shi. Obg-like ATPase 1 regulates global protein serine/threonine phosphorylation in cancer cells by suppressing the GSK3β- inhibitor 2-PP1 positive feedback loop.  Oncotarget. 2015. Dec. DOI: 10.18632/oncotarget.6496
              Wu H, Wang G(co-first author), Wang Z, An S, Ye P1 Luo S. A negative feedback loop between miR-200b and the NF-κB pathway via IKBKB/IKK-β in breast cancer cells. FEBS J. 2015 Oct 3. doi: 10.1111/febs.13543. [Epub ahead of print]
              Guo CF1, Liu Q, Wang G, Wang Y, Shi Z, Suo Z, Chu CW, Ren Z. Fatigue-free, superstretchable, transparent, and biocompatible metal electrodes. Proc Natl Acad Sci U S A. 2015 Sep 21. pii: 201516873.
              Huarong Chen1,2,*, Renduo Song1,*, Guohui Wang(co-first author)*, Zonghui Ding1 , ChunyingYang3 , Jiawei Zhang2 , Zihua Zeng4, Valentina Rubio1 , Luchang Wang1 , Nancy Zu1 , Amanda M. Weiskoff1 , Laurie J. Minze5 , Prince V.S. Jeyabal1 , Oula C. Mansour1 , Li Bai1 , William C. Merrick6, Shu Zheng2 & Zheng-Zheng Shi. OLA1 regulates protein synthesis and integrated stress response by inhibiting eIF2 ternary complex formation. Scientific Reports ,2015). doi:10.1038/srep13241
              Deng Z, Li Y, Fan J, Wang G, Li Y, Zhang Y, Cai G, Shen H, Ferrari M, Hu TY.  Circulating Peptidome to Indicate the Tumor-resident Proteolysis. Sci Rep. 2015 Mar 19;5:9327. doi: 10.1038/srep09327
              張偉光, 王國慧(通訊), 張衛東等 ,18氟-氟代脫氧葡萄糖PET/CT顯像與傳統影像探測乳腺癌治療后復發與轉移的臨床價值. 中華醫學雜志。 2013, 93(19): 1446-1449.
              張偉光,王國慧(通訊) 張衛東 樊衛 ·FDG PET/CT評估乳腺癌治療后淋巴結轉移的臨床價值。中山大學學報(醫學科學版) ,2013,2013, 34(1): 135-139.
              Guohui Wang, Gang Liu, Xiaogang Wang, Seema Sethi, Ali-Fehmi, Rouba, Judith Abrams , Ze Zheng, Kezhong Zhang, Stephen Ethier, and Zeng-Quan Yang . ERLIN2 promotes breast cancer cell survival by modulating endoplasmic reticulum stress pathways. BMC cancer. 2012 Jun 8;12(1):225.
              Guohui Wang, Xuebao Zhang , Xiaogang Wang, Zeng-Quan Yang, and Kezhong Zhang. Endoplasmic Reticulum Factor ERLIN2 Regulates Cytosolic Lipid Contents in Cancer Cells.  Biochemical journal. 2012 , Sep 15;446(3):415-25.
              Wang G, Wu Y, Zhang W, Li J, Wu P, Xie C. Clinical value of whole-body F-18 fluorodeoxyglucose positron emission tomography/computed tomography in patients with carcinoma of unknown primary. J Med Imaging Radiat Oncol. 2013 Feb;57(1):65-71.
              Zhang C, Wang G, Zheng Z, Maddipati KR, Zhang X, Dyson G, Williams P, Duncan SA, Kaufman RJ, Zhang K. ER-tethered transcription factor crebh regulates hepatic lipogenesis, fatty acid oxidation, and lipolysis upon metabolic stress. Hepatology. 2011 Nov 16. doi: 10.1002/hep.24783.
              Stevens JB, Abdallah BY, Liu G, Ye CJ, Horne SD, Wang G, Savasan S, Shekhar M, Krawetz SA, Hüttemann M, Tainsky MA, Wu GS, Xie Y, Zhang K, Heng HH. Diverse system stresses: common mechanisms of chromosome fragmentation. Cell Death Dis. 2011 Jun 30;2:e178. doi: 10.1038/cddis.2011.60.
              Guohui Wang, Zeng-Quan Yang, Kezhong Zhang: Endoplasmic reticulum stress response in cancer: molecular mechanism and therapeutic potential. Am J Transl Res 2010;2(1):65-74.
              Guohui Wang, Sanjay Rajagopalan, Qinghua Sun, and Kezhong Zhang. Real-world exposure of airborne particulate matter triggers oxidative stress in an animal model. Int J Physiol Pathophysiol Pharmacol 2010;2(1):64-68.
              Suzette Laing, Guohui Wang, Tamara Briazova, Chunbin Zhang, Aixia Wang, Ze Zheng, Alexander Gow, Alex F. Chen, Sanjay Rajagopalan, Lung Chi Chen, Qinghua Sun, and Kezhong Zhang. Airborne Particulate Matter Selectively Activates Endoplasmic Reticulum Stress Response in the Lung and Liver Tissues,  Am J Physiol Cell Physiol, 2010 Oct;299(4):C736-49
              王國慧, 何軍芳, 樊衛, 吳沛宏. 重組Ad-Cp-CDglyTK雙自殺基因腺病毒載體構建及體外抑制鼻咽癌細胞的實驗研究. 中國病理生理雜志. 2008,  24(2): 215-219.
              王國慧,Eddie W. F. Lau , Ramdave Shakher, Peter EU, Val Johnston , Rodney J. Hicks. 177Lu-octreotate治療神經內分泌胃腸胰腺腫瘤的SPECT顯像研究. 中華核醫學雜志, 2007, 27(5):313-314.
              王國慧, Eddie W. F. Lau , Ramdave Shakher, David S. Binns ,  Annette Hogg, Elizabeth Drummond , Rodney J. Hicks. 18F-FDG PET/CT顯像在鼻咽癌分期與療效監測中的臨床應用價值. 癌癥,2007,26(6): 638-642.
              王國慧, Eddie W.F. Lau, Ramdave Shakher, Robert E. Ware,  David S. Binns,  Annette Hogg, Elizabeth Drummond,Rodney J. Hicks. 18 F-FDG PET/CT 發現腫瘤患者意外病灶的臨床價值.  中華核醫學雜志, 2007, 27(1): 1-4.
              Guohui Wang, Eddie W. F.Lau, Ramdave Shakher,Danny Rischin, Robert E. Ware,Emily Hong,David S. Binns, Annette Hogg, , Elizabeth Drummond, Rodney J. Hicks, How do oncologists deal with incidental abnormalities on whole-body fluorine-18 fluorodeoxyglucose PET/CT? Cancer, 2007, 109(1):117-24.
              梁培炎, 王國慧, 李群, 楊小春, 張偉光, 蔡燕君.  99Tcm-HL91乏氧顯像在鼻咽癌治療中的應用. 中華核醫學雜志. 2006,26(2):97-99.
              吳沛宏,王國慧. 腫瘤MR分子影像學研究進展. 國外醫學(放射醫學核醫學分冊). 2005 Vol.29 No.3 P.139-142
              王國慧,劉長征,梁昌盛, 樊衛. 188Re-BAC5 對鼻咽癌的免疫導向治療的實驗研究,核技術,2003. 26(5): 375-379
              Wang guohui, Fan  Wei, Zhang Weiguang,et al . Clinical study of sentinel lymph nodes guided by combined isotope-dye technique in patients with lingual carcinoma. Chin Med J. 2003.116(8) :1213-1215
              王國慧,樊衛,張偉光,戴軍進, 楊小春, 彭漢偉. 核素顯像-染色法探測舌癌前哨淋巴結的臨床研究 .中華核醫學雜志. 2003. 23(3): 143-144
              王國慧,樊衛. 基因顯像在腫瘤治療中的作用(綜述). 腫瘤防治雜志, 2002.5suppl. :436-438.
              樊衛、王國慧, 楊名添 ,張偉光, 戴軍進 ,楊小春. 放射性碘131在荷乳腺癌裸鼠的生物分布與核素顯像的實驗研究,癌癥,2004, 23(7): 808-811。
              王國慧,樊衛, 張偉光.  SPECT聯合X線診斷鼻咽癌骨轉移的臨床研究,現代臨床醫學生物工程學雜志,2003, 9(6): 471-472
              樊衛、王國慧, 劉學奎 , 曾宗淵.  99TcmO4- 洗脫液動態顯像在頜下腺移位術中的臨床應用研究. 中華核醫學雜志. 2005,25(5):301-303。

           
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          • 上海衛生局
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