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          廣東威爾醫院,wellclinic,威爾醫院骨科
          醫院公益
          特邀專家

          門診時間(無假日醫院)
          早上8:00 - 晚上21:00

          緊急聯系電話:020-38063333

          陳金娜

          研究方向: 細胞生物學, 腫瘤遺傳學

          學習工作經歷
          博士后(Postdoctoral fellow) 解剖與細胞病理學系Department of Anatomical and Cellular Pathology, 香港中文大學The Chinese University of Hong Kong, 香港Hong Kong, Year 2015-2017年
          博士PhD.  臨床腫瘤學系Department of Clinical Oncology, 香港大學The University of Hong Kong, 香港Hong Kong, Year2011-2015年,
          碩士M.S. 分子醫學Department of Cancer Research, 中山大學腫瘤防治中心Sun Yat-Sen University Cancer Center, 廣州Guangzhou, 中國China, Year2008- 2011年
          理學學士B.S.  生物技術School of Biotechnology, 華南理工大學South China University of Technology, 廣州Guangzhou, 中國China, Year2004- 2008年

          研究課題與實驗技術
          1. 乙肝病毒及非酒精性脂肪肝相關肝細胞肝癌基因組和轉錄組生物信息學整合分析(主要參與者)。 Integrative analysis ofwhole genome andtranscriptome sequencing in hepatitis B virus (HBV) and Non-alcoholic steatohepatitis (NASH) related hepatocellular carcinoma (HCC). (Sub-project performer, Paper in preparation)
          2. 轉移性鼻咽癌新藥物靶點的轉錄組數據挖據和功能研究(課題設計與執行)。Transcriptome analysisand functional study of drugable targetsfor the treatment of metastatic nasopharyngeal carcinoma (NPC). (Project designer and performer, paper in preparation)
          3. 鼻咽癌早期診斷血清學miRNA生物分子標記物的篩選(主要執行者)。Screening of Epstein-Barr virus (EBV)miRNAs as serology markers for NPC early diagnosis. (Major performer,paper in preparation)
          4. 發現細胞分裂中期調控內質網和高爾基體協同細胞分裂的分子開關(分子開關的發現和關鍵機制探索)。Discovery of a novel molecular switch regulating endoplasmic reticulum(ER)and Golgi apparatus division during mitosis.(Molecule switch discovery and essential mechanism exploration, paper in preparation)
          5. DNA原位雜交遺傳診斷Genetic diagnosis by DNA FISH: 設計并合成DNA探針Design and generate DNA probes; 檢測血液細胞及活檢組織樣品中的基因擴增,缺失,融合,斷裂以及基因轉位Detection of gene amplification, deletion; gene fusion, breakdown and translocation in blood or tissue samples; 檢測基因突變Sequencing forthe detection of gene mutation.
          6. 分子生物學技術,不限于以下所述Techniques of molecular biology include but not limited to: 基因工程gene engineering;實時熒光定量PCR Quantitative Real-time PCR;蛋白質相互作用組學protein interactome; 質譜Mass spectrum; 共聚焦顯微技術Confocal microscopic; 流式細胞術Flow cytometry, 熒光標記活細胞成像live cell imaging, 熒光素酶,熒光蛋白標記腫瘤細胞追蹤和PET-CT活體動物成像live animal imaging for tumor tracing by luciferase, fluorescence and animal PET-CT.
          已發表文獻
          1. Chen JN, Xia WX, JiangC,Yu YH, Yang J, LiL, Zhang LF, Ma CQ, Ke LR, Xiang YQGuo X andGuanXY.EGFL6, a potential novel ligand of EGFR, play roles in cancer metastasis by inducing cancer cell Epithelial-Mesenchymal Transition in Nasopharyngeal Carcinoma. (In preparation)
          2. Alissa Michelle Wong, Jinna Chen, Stephanie Ma ,Aikha Melissa Wong , SaiWahTsao , Jiang-Chao Li , Yan Li , Dora L. Kwong , Janice Wing-Hang Tsang and Xin-Yuan Guan. Epstein-Barr Virus Encoded microRNAs Promotethe Development of Nasopharyngeal Carcinoma by Extensively Activating Wnt Signaling. (In preparation)
          3. Yang J*, Lv X*, Chen J*, Xie C, Xia WX, Jiang C, Zeng TT, Ye YF, Ke LR, Yu YH, Hu L, Guan XY, Guo X and Xiang YQ. CCL2-CCR2 axis promotes metastasis of nasopharyngeal carcinoma by activating ERK1/2-MMP2/9 pathway.Oncotarget.2016 Mar 29;7(13):15632-47. doi: 10.18632/oncotarget.6695.(* These authors contribute equate to this article).
          4. Li J, Chen JN, Zeng TT, He F, Chen SP, Ma S, Bi J, Zhu XF, Guan XY.CD133+ liver cancer stem cells resist interferon-gamma-induced autophagy.BMC Cancer. 2016 Jan 13;16:15. doi: 10.1186/s12885-016-2050-6.
          5. Xu L, Li X, Cai M, Chen J, Li X, Wu WK, Kang W, Tong J, To KF, Guan XY, Sung JJ, Chan FK, Yu J. Increased expression of Solute carrier family 12 member 5 via gene amplification contributes to tumour progression and metastasis and associates with poor survival in colorectal cancer.Gut. 2015 May 6. pii: gutjnl-2014-308257. doi: 10.1136/gutjnl-2014-308257.
          6. Liu L, Dai Y, Chen J, Zeng T, Li Y, Chen L, Zhu YH, Li J, Li Y, Ma S, Xie D, Yuan YF, Guan XY.Maelstrom promotes hepatocellular carcinoma metastasis by inducing epithelial-mesenchymal transition by way ofAkt/GSK-3β/Snail signalling. Hepatology. 2014 Feb;59(2):531-43. doi: 10.1002
          7. Tong M, Chan KW, Bao JY, Wong KY, Chen JN, Kwan PS, Tang KH, Fu L, Qin YR, Lok S, Guan XY, Ma S.Rab25 is a tumor suppressor gene with antiangiogenic and anti-invasive activities in esophageal squamous cell carcinoma. Cancer Res. 2012 Nov 15;72(22):6024-35. doi: 10.1158
          8. 7. Zou Z, Yuan Z, Zhang Q, Long Z, Chen J, Tang Z, Zhu Y, Chen S, Xu J, Yan M, Wang J, Liu Q.Aurora kinase A inhibition-induced autophagy triggers drug resistance in breast cancer cells. Autophagy. 2012 Dec;8(12):1798-810. doi: 10.4161
           
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          • 國家衛生部
          • 國家食藥監局
          • 中國醫師協會
          • 中華醫學會
          • 上海衛生局
          • 世界衛生組織